_1597134364
1597134364
Hamid Shirkhanloo
sahar.zi67@gmail.com
Hamid Shirkhanloo
Analytical Methods in Environmental Chemistry Journal
AMECJournal
2645-5382
2645-5552
06
25
2020
3
02
10.24200/amecj.v3.i02
http://journal.amecj.com/index.php/AMECJ-01/issue/view/12
Determination and prediction of peptide mobilities by micellar electro-kinetic chromatography using adaptive neuro-fuzzy inference system as a feature selection method
Mustafa
Sadi
Morteza
G. Khaledi
Mehdi
Jalali-Heravi
Mobility of 128 peptides composed of up to 14 amino acids is determined for sodium dodecyl sulfate (SDS) micellar systems using micellar electrokinetic chromatography (MEKC). The mobilities of these peptides are predicted using back propagation of error artificial neural networks (BP-ANNs). Adaptive neuro-fuzzy inference system (ANFIS) which can deal with linear and nonlinear phenomena is used to select the inputs of BP-ANN. A 3:4:1 BP-ANN model with four variables of Kappa substituent constant, Kappa(H), number of peptide bonds, (ln(N), molar refractivity of C-terminal, MRC, and steric effects at N-terminal, ES,N, which incorporate substituent, steric and molar refractivity effects as its inputs was developed. Comparison of Multiple Linear Regression (MLR) and ANN results shows the nonlinear characteristic of the phenomena. The nonlinear model was successful in predicting the mobilities of 120 peptides except for the ones (8 peptides) with negatively charged amino acids.
06
30
2020
5
20
http://creativecommons.org/licenses/by/4.0
10.24200/amecj.v3.i02.98
http://journal.amecj.com/index.php/AMECJ-01/article/view/98
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http://journal.amecj.com/index.php/AMECJ-01/article/download/98/193
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http://journal.amecj.com/index.php/AMECJ-01/article/download/98/193